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Index > Protein center > Hcn4(Gene name) > Rat
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  • Hcn4 (Gene name),
  • Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Protein name ),  HCN4_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Hcn4;
    Protein name:
    Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.
    Function:
    Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1198
    Sequence:
    50:
    MDKLPPSMRK | RLYSLPQQVG | AKAWIMDEEE | DGEEEGAGGL | QDPSRRSIRL | 
    100:
    RPLPSPSPSV | AAGCSESRGA | ALGAADSEGP | GRSAGKSSTN | GDCRRFRGSL | 
    150:
    ASLGSRGGGS | GGAGGGSSLG | HLHDSAEERR | LIAAEGDASP | GEDRTPPGLA | 
    200:
    TEPERPGAAA | QPAASPPPQQ | PPQPASASCE | QPSADTAIKV | EGGAAASDQI | 
    250:
    LPEAEVRLGQ | SGFMQRQFGA | MLQPGVNKFS | LRMFGSQKAV | EREQERVKSA | 
    300:
    GFWIIHPYSD | FRFYWDLTML | LLMVGNLIII | PVGITFFKDE | NTTPWIVFNV | 
    350:
    VSDTFFLIDL | VLNFRTGIVV | EDNTEIILDP | QRIKMKYLKS | WFVVDFISSI | 
    400:
    PVDYIFLIVE | TRIDSEVYKT | ARALRIVRFT | KILSLLRLLR | LSRLIRYIHQ | 
    450:
    WEEIFHMTYD | LASAVVRIVN | LIGMMLLLCH | WDGCLQFLVP | MLQDFPHDCW | 
    500:
    VSINGMVNNS | WGKQYSYALF | KAMSHMLCIG | YGRQAPVGMS | DVWLTMLSMI | 
    550:
    VGATCYAMFI | GHATALIQSL | DSSRRQYQEK | YKQVEQYMSF | HKLPPDTRQR | 
    600:
    IHDYYEHRYQ | GKMFDEESIL | GELSEPLREE | IINFNCRKLV | ASMPLFANAD | 
    650:
    PNFVTSMLTK | LRFEVFQPGD | YIIREGTIGK | KMYFIQHGVV | SVLTKGNKET | 
    700:
    KLADGSYFGE | ICLLTRGRRT | ASVRADTYCR | LYSLSVDNFN | EVLEEYPMMR | 
    750:
    RAFETVALDR | LDRIGKKNSI | LLHKVQHDLN | SGVFNYQENE | IIQQIVRHDR | 
    800:
    EMAHCAHRVQ | AAASATPTPT | PVIWTPLIQA | PLQAAAATTS | VAIALTHHPR | 
    850:
    LPAAIFRPPP | GPGLGNLGAG | QTPRHPRRLQ | SLIPSALGSA | SPASSPSQVD | 
    900:
    TPSSSSFHIQ | QLAGFSAPPG | LSPLLPSSSS | SPPPGACSSP | PAPTPSTSTA | 
    950:
    ATTTGFGHFH | KALGGSLSSS | DSPLLTPLQP | GARSPQAAQP | PPPLPGARGG | 
    1000:
    LGLLEHFLPP | PPSSRSPSSS | PGQLGQPPGE | LSPGLAAGPP | STPETPPRPE | 
    1050:
    RPSFMAGASG | GASPVAFTPR | GGLSPPGHSP | GPPRTFPSAP | PRASGSHGSL | 
    1100:
    LLPPASSPPP | PQVPQRRGTP | PLTPGRLTQD | LKLISASQPA | LPQDGAQTLR | 
    1150:
    RASPHSSGES | MAAFSLYPRA | GGGSGSSGGL | GPPGRPYGAI | PGQHVTLPRK | 
    1198:
    TSSGSLPPPL | SLFGARAASS | GGPPLTAAPQ | REPGARSEPV | RSKLPSNL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Cat.:
    E13654h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Cat.:
    E13654r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Cat.:
    E13654m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Cat.:
    U13654h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Cat.:
    U13654m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Polyclonal Antibody for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Polyclonal Antibody for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Polyclonal Antibody for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Monoclonal Antibody for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Monoclonal Antibody for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Monoclonal Antibody for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Monoclonal Antibody for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Protein for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Protein for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Protein for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
    Protein for Rat Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

    R&D Technical Data


     

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli."
      Stevens D.R. , Seifert R. , Bufe B. , Mueller F. , Kremmer E. , Gauss R. , Meyerhof W. , Kaupp U.B. , Lindemann B.
      Nature413:631-635(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain."
      Monteggia L.M. , Eisch A.J. , Tang M.D. , Kaczmarek L.K. , Nestler E.J.
      Brain Res. Mol. Brain Res.81:129-139(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      strain: Sprague-Dawley.
      tissue: Brain.
    3. 3.
      "Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues."
      Shi W. , Wymore R. , Yu H. , Wu J. , Wymore R.T. , Pan Z. , Robinson R.B. , Dixon J.E. , McKinnon D. , Cohen I.S.
      Circ. Res.85:1-6(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 262-428
      tissue: Heart.
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